Sexual dysfunction effectively is a major problem facing the reproductive process. In ayurvedic medicine Coriandrum Sativum (Linn) is a fruit-used as aphrodisiac, In case of stress modulated sexual behavior in male rats, high and medium dose of Coriandrum Sativum (Linn.) extract significantly decreased the body weight difference between day 1 and day28 and increased the weight of testes, vasdeferens, seminal vesicles, epididymis and produced no change in weight of adrenal glands Coriandrum Sativum (Linn.) extract showed significant increase in sperm count and % of sperm motility when compared to stressed rats. In case of histopathology of testis, treatment of Coriandrum Sativum (Linn.) extract in the rats overcomes the single layer of spermatogenesis, congested blood vessels and absence of spermatozoa due to stress and also improves predominance of spermatocytes and increase in number of sertoli cells.

Cyclea Peltata extract has many important medical uses which makes it a potential extract for researchers prospecting for active compounds in an effort to provide intervention for the global antimicrobial pandemic especially in resource limited setting. The objective is to determine the Anti-asthmatic activity of Aqueous and Etanolic extract of Cyclea Peltata. The effect of Antiashmatic activity studied using Guinea pig ileum preparation (In vitro), histamine induced bronchospasm in Guinea pig (In vivo). In vitro study indicated that the alcoholic and aqueous extracts of Cyclea Peltata relaxed significantly ileum, pre-contracted by histamine. In vivo study of ethanolic and aqueous extracts of Cyclea Peltata to guinea pigs had shown the significant increase in preconvulsion time when the guinea pigs were exposed to histamine. The results of present investigation suggest that, ethanolic and aqueous extracts of Cyclea Peltata have significant bronchodilatory activity against histamine.

Aim: The aim of the present study is an attempt to formulate and evaluate niosomal drug delivery of Stavudine by using cholesterol and span 60 as a surface active agent for potentially treating HIV infection. Method: The formulations FS1-FS5 were prepared by varying the concentration of cholesterol and surfactant (span 60) by thin film hydration method. The formulation variable like concentration of surfactant and cholesterol significantly affected the in vitro drug release from the prepared formulations. The in vitro drug release studies were performed in phosphate buffer pH 7.4. Results: Drug and physical mixture were characterised by FTIR and DSC, the result of IR and DSC study showed that no interaction between drug and polymers and other formulation parameters like vesicle size, drug content, entrapment efficiency and in vitro release of formulated niosomes were evaluated which showed better results. Formulation prepared by thin film hydration method showed proper controlleddrug release after 24 hrs of dissolution studies. Conclusion: The main objective of this study was to design suitable niosome encapsulated drug delivery for antiretroviral drugs like stavudine, to study the in vitro behaviour of the prepared system and to investigate the niosome encapsulated drug for its activity. Finding of all this investigation conclusively demonstrate prolongation of drug release at a controlled rate, after encapsulation of stavudine. It shows that niosomal drug delivery system may be a promising carrier for the novel drug delivery system.