The aim of present research was to formulate fast disintegrating sublingual tablets of Timolol maleate for the emergency treatment of hypertension and also to avoid the first-pass metabolism and to improve its bioavailability. The tablets were prepared by direct compression method by utilizing 32 factorial design by incorporation of two super-disintegrants croscarmellose sodium and carboxymethyl cellulose sodium. FTIR studies showed compatibility between drug and excipients. The formulations were evaluated for Pre compression and post compression parameters (hardness, thickness, weight variation, wetting time, water absorption ratio, friability, content uniformity, disintegration time, In-vitro dissolution and stability studies). Formulation F4 showed disintegration time of 20 seconds and 97.42 % drug release in 12 minutes with super case II transport mechanism and all parameters with significant results. F4 showed stability even after 90 days time period, so it is considered as the best formulation. We successfully developed the sublingual tablets of Timolol male ate.

The purpose of this investigation was to study the microorganism associated with the spoilage of fresh fruits of tomato, Lycopersicum esculentum obtained from Tenkasi, kadayanallur, in Tamilnadu, India. A total of some species of bacteria isolated and identified by the different morphological identification of organism by Gram staining technique and Hanging drop technique. Biochemical tests such as Catalase test, Coagulase test, Indole test and Suger fermentation test was characterized to find out the enzymes which are released by the above microorganisms. The antibiotics sensitivity nature of the above microorganisms was done by Disc diffusion method by using narrow and broad spectrum standards. The above identified microorganisms has highest resistance and less sensitivity towards mentioned antibiotics standards. It gives the intimations for us about the consumption of spoiled tomato fruits.

A number of novel drug delivery systems have emerged encompassing numerous routes of administration, to realize controlled and targeted drug delivery, magnetic magnetic drug delivery system being one amongst them. These magnetic magnetic drug delivery system embrace magnetic microspheres, magnetic liposomes, magnetic nanoparticles, magnetic resealed erythrocytes, magnetic emulsion etc. Magnetic micro/nanoparticles and molecular magnetic labels are used for excellent variety of application in numerous areas of biosciences, targeted drug delivery, imaging and in bio separation technology. These comes can discuss regarding principle of magnetic targeting, mechanism of magnetic targeted drug delivery, edges and downsides of magnetic targeting, magnetic microcarriers and application of magnetism in targeted drug delivery and a few alternative field. Magnetically targeted drug delivery by particulate carriers is AN economical technique of delivering medicine to localized sickness sites like tumours. High concentrations of therapy or imaging agents are often achieved close to the target website with none ototoxic effects to traditional encompassing tissue. Non-targeted applications of magnetic microspheres and nanospheres embrace their use as distinction agents and as drug reservoirs that may be activated by a magnet applied outside the body. Historic and current applications of magnetic drug delivery system are mentioned, further as future directions and issues to be overcome for the economical and useful use of magnetic carriers in clinical observe.