Colorectal cancer has a high proportion of people infected in the world and if detected early, there is a high possibility of cure. The writing focuses on valuating markers of concentrations of CEA, CA 19-9 and some biochemical parameters in patients with colorectal cancer after surgery and treatment for colorectal cancer. Cross-sectional study is implemented on 162 patients with colorectal cancer who underwent surgeries at Vietnam - Czech Friendship Hospital, Vietnam. The results show that average age of women in the study is 64, 4±10, 6 which is higher than men (56, 7±11, 1) (p<0, 05). CEA concentration before surgery is 3,75 ng/ml which is higher than the CEA concentration after surgery for 1-3 months at 1, 93 ng/ml and after surgery for 3 to 6 months at 2, 19 ng/ml (p <0, 05). CEA concentration before surgery is 30, 96 ng/ml which is higher than the CEA concentration after surgery for 1-3 months at 23, 33 ng/ml, but being lower after surgery for 3 to 6 months at 61,0 ng/ml (p <0, 05). The concentration of CA19-9 has changes before and after the surgery, but the difference is not statistically significant. There was no differences before and after surgery between biochemical indices such as urea, creatinine, GOT and GPT; therefore, CEA in combination with CA19-9 increases the accuracy of the diagnosis, prognosis and monitoring for the colorectal cancer.

Rutin-flavonoid-polyphenolic has gained attention in prevention of brain cancer. The low permeability of Rutin (RU) across the blood-brain-barrier (BBB) leads to its insufficient delivery which in turns result in low therapeutic index. Therefore, developing a novel approaches enhancing the CNS delivery of RU are required for the treatment of Cancer. The aim of this research work was to develop in Nanoemulsion (NE) loaded with RU, for CNS targeting. Rutin (RU) is a poorly water soluble anticancer drug, with oral bioavailability is about 2%. Nanoemulsion (NE) were fabricated by Vortexing technique. Oleic acid was used as oil. Tween 80 was employed as surfactant and Polyethylene glycol 400 was employed as co-surfactant. RU loaded NE for intranasal delivery are considered as promising vehicle for its targeting to CNS to treat the brain cancer.

The present investigation was to formulate controlled release of muco adhesive tablets of clarithromycin followed by it’s evaluation studies. The tablets were formulated by using clarithromycin as drug, used for the treatment of H.pylori infection in peptic ulcer. The natural polysaccharides like, Tamarind Seed Polysaccharide (TSP), obtained from Tamarindus indica and chitosan were used as polymer material for controlled drug release. The formulated tablets of such different polymer were compared for different evaluation studies. The pre formulation studies were performed by using FTIR, DSC studies. The tablets were evaluated for in-process, in-vitro studies. The bioadhesive strength of tablets and polymers were comparatively determined by ex-vivo methods. The selected formulation were subjected to stability studies, the study concluded that Tamarind polysaccharide loaded tablets are more adhesive than chitosan loaded tablets. TSP is the best natural polymer for mucoadhesive due to biodegradability and controlled release mechanism.