A simple, highly versatile and an efficient synthesis of 2, 4, 5-trisubstituted imidazole that was obtained by three component cyclocondensation of benzil, substituted aromatic aldehydes and ammonium acetate in solvent free condition using camphor sulphonic acid acts as catalyst. The main advantages of this method of process are cost effectiveness of catalyst, easy work-up and purification of products by non-chromatographic methods, good to excellent yields and very short reaction time. One pot multicomponent reactions are very usefully an important an outstanding status in organic synthesis and medicinal chemistry for their high degree of atom economy and application in the diversity-oriented convergent conventional synthesis of complex organic molecules from simple and readily available substrates in a single vessel. The newly synthesized derivatives were evaluated by advanced spectroscopic data such as FTIR, ¹HNMR, ¹³CNMR and LCMS and the structural determination of the desired compounds were determined by elemental analysis.

A simple, highly versatile and an efficient pathway of synthesis of a novel series of 4-(4, 5-diphenyl-1H-imidazol-2-yl)-N-phenylbenzamide analogous. These derivatives can be obtained from4-(4, 5-diphenyl-1H-imidazol-2-yl) benzoic acid with substituted aromatic amine in the presence of Mg (NO₃)₂ 6H₂O as a low-cost and readily available catalyst in ethanol as solvent. 4-(4, 5-diphenyl-1H-imidazol-2-yl) benzoic acid can be synthesized from the mixture of benzil, carboxy benzaldehyde and ammonium acetate in acetic acid in the presence of molecular iodine at 70^oC. The main advantages of this process are cost effectiveness of catalyst, easy work-up and purification of products by non-chromatographic methods, excellent yields and very low reaction time. The newly obtained derivatives were confirmed by advanced spectroscopic data such as FTIR, 1HNMR, 13CNMR and LCMS and the structural determination of the desired compounds were determined by elemental analysis.

Extensive computational studies of the N-(5-(3-(1H-indol-3-yl) propyl)-1, 3, 4-thiadiazol-2-yl)-1-phenylmethanimine from thiazolidine (2) amine and substituted aldehydes in the presence of methanesulphonic acid. The compound (2) can be synthesized from an indole butyric carboxylic acid with thiocemicarbazide in the presence of protic acid. The newly synthesized derivatives were evaluated by advanced spectroscopic data such as FTIR, ¹HNMR, ¹³CNMR and LCMS and the structural determination of the desired compounds were determined by elemental analysis.